Hypocalcaemia increases the narcotic effect of codeine.
نویسنده
چکیده
Severe narcosis occurred in a patient with hypoparathyroidism given therapeutic doses of codeine phosphate.
منابع مشابه
Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs
Narcotic antitussives such as codeine reveal the antitussive effect primarily via the mu-opioid receptor in the central nervous system (CNS). The kappa-opioid receptor also seems to contribute partly to the production of the antitussive effect of the drugs. There is controversy as to whether delta-receptors are involved in promoting an antitussive effect. Peripheral opioid receptors seem to hav...
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the accumulation of active metabolites; and an interaction between dihydrocodeine and endogenous opiate-like peptides. Levine3 described an increased narcotic effect of codeine phosphate associated with hypocalcaemia in renal failure; our patient, however, remained normocalcaemic. The convulsions might possibly have been due to toxic dihydrocodeine concentrations,4 but hypertensive encephalo-pa...
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A severe degree of hypotension in children followed the intravenous administration of codeine phosphate in several case reports—histamine release was its presumed root cause [1–3]. We also report cardiovascular collapse following accidental bolus intravenous injection of 30 mg (74 μmol) codeine phosphate, but it was associated with a surprising profound degree of hypocalcaemia. A quantitative a...
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 56 660 شماره
صفحات -
تاریخ انتشار 1980